Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel α-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
Hong-Xu Xie, Juan Zhang, Yue Li, Jinhe Zhang, Shan-Kui Liu, Jie Zhang, Hua Zheng, Guizhou Hao, Kongkai Zhu, Cheng‐Shi Jiang
Topics & Concepts
AcarboseChemistryIn vivoDocking (animal)IC50UreaEnzymeBiochemistryIn silicoNon-competitive inhibitionEnzyme kineticsPharmacologyStereochemistryActive siteIn vitroMedicineBiotechnologyGeneNursingBiologyNatural Antidiabetic Agents StudiesEnzyme Production and CharacterizationAdvanced Glycation End Products research