Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin for an enhanced photodynamic therapy <i>in vitro</i> and <i>in vivo</i>
Ziyue Xu, Weipeng Mao, Zizhen Zhao, Zekun Wang, Yue-Yang Liu, Yan Wu, Hui Wang, Dan‐Wei Zhang, Zhan‐Ting Li, Da Ma
Abstract
Self-assembled nanoparticles based on supramolecular-organic frameworks and temoporfin demonstrate improved photo cytotoxicity in vitro and anti-tumor efficacy in vivo due to a reduced aggregation-induced quenching effect.
Topics & Concepts
In vivoPhotodynamic therapySupramolecular chemistryIn vitroMaterials scienceNanoparticleCytotoxicityNanotechnologyQuenching (fluorescence)BiophysicsChemistryFluorescenceOrganic chemistryBiochemistryMoleculeBiologyQuantum mechanicsPhysicsBiotechnologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging