Outcomes of critically ill patients with acute kidney injury in COVID-19 infection: an observational study
Rodrigo Bezerra, Flávio Teles, Polyana Bezerra Mendonca, Tedla Damte, Andrew Likaka, Edyniesky Ferrer-Miranda, Jones Oliveira de Albuquerque, José Luiz de Lima Filho
Abstract
BACKGROUND: Early reports indicate that AKI is common during COVID-19 infection. Different mortality rates of AKI due to SARS-CoV-2 have been reported, based on the degree of organic dysfunction and varying from public to private hospitals. However, there is a lack of data about AKI among critically ill patients with COVID-19. METHODS: We conducted a multicenter cohort study of 424 critically ill adults with severe acute respiratory syndrome (SARS) and AKI, both associated with SARS-CoV-2, admitted to six public ICUs in Brazil. We used multivariable logistic regression to identify risk factors for AKI severity and in-hospital mortality. RESULTS: < 0.001). CONCLUSION: Critically ill patients with SARS and AKI due to COVID-19 had high mortality in this cohort. Mortality was largely determined by the need for mechanical ventilation and vasopressors rather than AKI severity.