Research Progress in Elucidating the Mechanisms Underlying ResveratrolAction on Lung Cancer
Chunguang Li, Yu‐Shui Ma, Da Fu, Rui Xin, Biao Shen, Zhong-Yan Huang, Jibin Liu, Sha Li, Geng-Xi Jiang, Jie Zhang, Ya-Hong Cao, Da-Zhi Zou, Wen Li
Abstract
Resveratrol has several functions, including protection of the heart and nervous system and exerts antidiabetic, anti-inflammatory, anti-aging, and antitumor effects. It is reported to impede the occurrence and development of tumors in cancer cell lines, animal models, and clinical studies. In vitro and in vivo experiments show that it exerts preventive or adjuvant therapeutic effects in pancreatic, colorectal, prostate, liver, and lung cancers. Mechanistic research reports show that resveratrol can induce tumor cell apoptosis and autophagy, inhibit cell cycle and angiogenesis, regulate nuclear factors and cyclooxygenase signal transduction pathways, and inhibit carcinogens' metabolic activation and alter tumor-related expression patterns; anti-oxidation affects tumor cell proliferation, metastasis, and apoptosis. However, the exact mechanism underlying its action remains unclear. This review highlights multiple aspects of the biological impacts and mechanisms underlying resveratrol action on the occurrence and development of lung cancer.