Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability
Nurfazreen Anuar, Akmal Hidayat Bin Sabri, Tommy Julianto Bustami Effendi, Khuriah Abdul Hamid
Abstract
studies using rat model that highlighted a two-fold increase in ibuprofen absorption when the drug was administered as a nanoemulsion relative to drug-in-oil system. On the other hand, when ibuprofen was administered as microemulsions, only a 1.5-fold increase in absorption was observed relative to drug-in-oil system. Thus, this study highlights the potential of using nanoemulsion as a drug delivery system to enhance the oral bioavailability of hydrophobic drugs.
Topics & Concepts
BioavailabilityIbuprofenDrug deliveryDrugExcipientSolubilityChemistryAbsorption (acoustics)ChromatographyPharmacologyMicroemulsionPharmacokineticsIn vivoMaterials sciencePulmonary surfactantMedicineOrganic chemistryBiochemistryBiotechnologyBiologyComposite materialDrug Solubulity and Delivery SystemsSurfactants and Colloidal SystemsAdvanced Drug Delivery Systems