Pathomorphological sequence of nephron loss in diabetic nephropathy
Jana Löwen, Elisabeth Gröne, Marie-Luise Groß-Weißmann, Felix Bestvater, Hermann‐Josef Gröne, Wilhelm Kriz
Abstract
Based on analysis of 918 human biopsies, essential derangement in diabetic nephropathy consists of accumulation of worn-out glomerular basement membrane in the mesangium that may advance to global sclerosis. The most frequent pathway to nephron dropout starts with the penetration of glomerular capillaries into Bowman's capsule (BC), delivering an exudate into BC that spreads around the entire glomerular circumference and via the glomerulotubular junction onto the tubule, resulting in glomerular sclerosis and chronic tubulointerstitial damage.
Topics & Concepts
Diabetic nephropathyNephronSequence (biology)UrologyMedicineNephropathyDiabetes mellitusInternal medicineEndocrinologyBiologyKidneyBiochemistryChronic Kidney Disease and DiabetesRenal Diseases and GlomerulopathiesBiomedical Research and Pathophysiology