A bovine milk-derived peptide ameliorates pancreatic β-cell dedifferentiation through PI3K/Akt/FOXO1 signaling in type 2 diabetes
Yunbiao Lu, Rongrong Huang, Zhongkan Sun, Yu Ou
Abstract
LGP9 reverses the occurrence of islet β-cells dedifferentiation and EMT in vitro and in vivo through the PI3K/Akt/FOXO1/PDX1/E-Cadherin signaling pathway in T2DM.
Topics & Concepts
FOXO1Protein kinase BPI3K/AKT/mTOR pathwayEndocrinologyIsletInternal medicinePancreatic isletsDownregulation and upregulationWestern blotCellSignal transductionChemistryBiologyInsulinCell biologyMedicineBiochemistryGenePancreatic function and diabetesFOXO transcription factor regulationDiabetes and associated disorders