Decyclization of Substituted 2-[2-Oxofuran-3(2H)-ylidene)furan-2-carbohydrazides by the Action of Alcohols and Analgesic Activity of the Obtained Compounds
S. N. Igidov, A. Yu. Turyshev, Р. Р. Махмудов, D. A. Shipilovskikh, М. В. Дмитриев, O. V. Zvereva, P. S. Silaichev, Н. М. Игидов, Sergei A. Shipilovskikh
Abstract
Abstract A new series of substituted 4-oxo-2-[2-(furan-2-ylcarbonyl)hydrazinylidene]butanoic acids and 2-[2-oxofuran-3(2H)-ylidene]furan-2-carbohydrazides was synthesized. A methodology was developed for their decyclization under the action of primary and secondary alcohols with the formation of substituted alkyl 4-oxo-2-[2-(furan-2-ylcarbonyl)hydrazinylidene]butanoates, which exist in the form of three isomeric forms. Among the synthesized compounds, substances with pronounced analgesic activity were found.
Topics & Concepts
ChemistryFuranAlkylOrganic chemistryAnalgesicMedicinal chemistryStereochemistryPharmacologyMedicineChemical synthesis and pharmacological studiesSynthesis and Reactions of Organic CompoundsStructural and Chemical Analysis of Organic and Inorganic Compounds