Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity
Kyoko Chiba, Kassandra M Ori-McKenney, Shinsuke Niwa, Richard J. McKenney
Abstract
(Cell Reports 39, 110900, May 31, 2022) In the originally published version of this paper, an incorrect definition for the term “MAP7” was introduced during the production process. The correct definition for MAP7 is “microtubule-associated protein 7,” which now appears with the article online. The production team apologizes for the error. Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activityChiba et al.Cell ReportsMay 31, 2022In BriefKinesin-1 (KIF5) transports cargo along microtubules. The mechanism of KIF5 movement is understood, but how the motor is autoinhibited and activated remains unclear. Chiba et al. report both synergistic autoinhibition and activation of the KIF5 tetramer and suggest that predominant models in the field for these processes need revision. Full-Text PDF Open Access