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Co-delivery of IL-12 cytokine gene and cisplatin prodrug by a polymetformin-conjugated nanosystem for lung cancer chemo-gene treatment through chemotherapy sensitization and tumor microenvironment modulation

Yue Sun, Jiayu Yang, Tong Yang, Yifan Li, Rongyue Zhu, Yanhui Hou, Yanhua Liu

2021Acta Biomaterialia44 citationsDOI

Topics & Concepts

ChemoimmunotherapyCancer researchCisplatinProdrugGene deliveryTumor microenvironmentPharmacologyChemotherapyGenetic enhancementLung cancerImmune systemMedicineImmunotherapyImmunologyBiologyInternal medicineGeneBiochemistryNanoplatforms for cancer theranosticsRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery
Co-delivery of IL-12 cytokine gene and cisplatin prodrug by a polymetformin-conjugated nanosystem for lung cancer chemo-gene treatment through chemotherapy sensitization and tumor microenvironment modulation | Litcius