Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity
Wenchong Ye, Qun Tang, Tiantian Zhou, Cui Zhou, Chuangchuang Fan, Xiaoyang Wang, Chunmei Wang, Keyu Zhang, Guochao Liao, Wen Zhou, Guochao Liao, Wen Zhou
Topics & Concepts
ChemistryAsialoglycoprotein receptorCytotoxicityGlycoconjugateInternalizationDoxorubicinGalactoseHepatocellular carcinomaConjugateBiochemistryCancer researchIn vitroCellHepatocyteChemotherapyBiologyMathematical analysisGeneticsMathematicsGlycosylation and Glycoproteins ResearchNatural product bioactivities and synthesisMicrobial Natural Products and Biosynthesis