Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents
Buthina A. Al-Oudat, Hana’a M. Jaradat, Qosay Al‐Balas, Nizar A. Al‐Shar’i, A Bryant-Friedrich, Mel Bedi
Topics & Concepts
ChemistryLactoylglutathione lyaseMoietyDocking (animal)Combinatorial chemistryEnzymeStereochemistryIn vitroStructure–activity relationshipChemical synthesisBiochemistryPharmacologyComputational biologyGlutathioneNursingMedicineBiologyEnzyme Production and CharacterizationEnzyme function and inhibitionAdvanced Glycation End Products research