Palladium-catalyzed asymmetric allylic alkylation (AAA) with alkyl sulfones as nucleophiles
Barry M. Trost, Zhiwei Jiao, Hadi Gholami
Abstract
A variety of “hard” α-sulfonyl carbanions of aryl, heteroaryl and alkyl sulfones were successfully employed as nucleophiles in palladium-catalyzed asymmetric allylic alkylation with excellent enantioselectivities.
Topics & Concepts
NucleophileCarbanionSulfonylTsuji–Trost reactionPalladiumAlkylAlkylationChemistryArylCatalysisAllylic rearrangementAminationOrganic chemistryMedicinal chemistryAsymmetric Synthesis and CatalysisAsymmetric Hydrogenation and CatalysisCatalytic C–H Functionalization Methods