DLK-Dependent Biphasic Reactivation of Herpes Simplex Virus Latency Established in the Absence of Antivirals
Sara A. Dochnal, Husain Y. Merchant, Austin R. Schinlever, Aleksandra Babnis, Daniel P. Depledge, Angus C. Wilson, Anna R. Cliffe
Abstract
. Using this model, we find that initial reactivation events are dependent on cellular stress kinase DLK but independent of histone demethylase activity and viral DNA replication. Our data therefore further validate the essential role of DLK in mediating a wave of lytic gene expression unique to reactivation.
Topics & Concepts
BiologyHerpes simplex virusVirologyLatency (audio)Virus latencyVirusSimplexvirusHSL and HSVHerpesviridaeAlphaherpesvirinaeViral replicationMicrobiologyViral diseaseElectrical engineeringEngineeringHerpesvirus Infections and TreatmentsRNA regulation and diseaseinterferon and immune responses