TRAF4 regulates ubiquitination-modulated survivin turnover and confers radioresistance
Jinzhuang Liao, Qing Xiang, Xiaoying Li, Gan Yu, Ruirui Wang, Shuangze Han, Wěi Li, Wei Song
Abstract
and the xenograft mouse model. Altogether, our study highlights the TRAF4-survivin axis as a potential therapeutic target for radiosensitization in NPC.
Topics & Concepts
RadioresistanceSurvivinNasopharyngeal carcinomaCancer researchGene knockdownProtein kinase BRadiosensitivityCyclin-dependent kinase 1MedicineCancerBiologyCell cycleRadiation therapySignal transductionCell cultureInternal medicineCell biologyGeneticsNF-κB Signaling PathwaysCell death mechanisms and regulationCancer-related Molecular Pathways