DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders
Kyra Feuer, Xi Peng, Christian Yovo, Dimitrios Avramopoulos
Topics & Concepts
Induced pluripotent stem cellBiologyTranscriptomeKnockout mousePI3K/AKT/mTOR pathwayNeuroscienceGene isoformNeurogenesisGlutamatergicGenome-wide association studySchizophrenia (object-oriented programming)Signal transductionGeneticsGeneGene expressionMedicinePsychiatryGlutamate receptorSingle-nucleotide polymorphismReceptorEmbryonic stem cellGenotypeGenetics and Neurodevelopmental DisordersRNA Research and SplicingCellular transport and secretion