Micro-environment triple-responsive hyaluronic acid hydrogel dressings to promote antibacterial activity, collagen deposition, and angiogenesis for diabetic wound healing
Wenquan Wang, Jingxia Zheng, Xiao-Jing Hong, Jiaying Zhou, Yuwen Xiong, Hailong Yang, Shengnan Li, Guoqi Chen, Qiao Su, Wenwen Li, Bin Cheng, Jun Fu, Tong Wu
Abstract
experiments on diabetic mice demonstrate that the hydrogel dressing highly promotes angiogenesis and extracellular matrix (ECM) deposition, leading to eventual full healing of diabetic skin wounds. This micro-environment-triggered triple-responsive drug release provides a promising method for chronic diabetic wound healing.
Topics & Concepts
Hyaluronic acidWound healingAngiogenesisAntibacterial activityWound dressingBiomedical engineeringMaterials sciencePharmacologyCancer researchMedicineBacteriaSurgeryComposite materialAnatomyBiologyGeneticsWound Healing and TreatmentsElectrospun Nanofibers in Biomedical ApplicationsPeriodontal Regeneration and Treatments