Hyaluronidase Coated Molecular Envelope Technology Nanoparticles Enhance Drug Absorption via the Subcutaneous Route
Ramesh Soundararajan, George Wang, Asya Petkova, Ijeoma F. Uchegbu, Andreas G. Schätzlein
Abstract
CUDC-101 increased the survival time from 15 days (control animals treated with hyaluronidase alone) to 43 days. Polymer MET nanoparticles coated with hyaluronidase enabled the subcutaneous delivery of a hydrophobic drug with favorable therapeutic outcomes.
Topics & Concepts
ChemistryPharmacologyHyaluronidaseDrugPharmacokineticsBioavailabilityDrug deliveryChitosanNanoparticleBiochemistryNanotechnologyMedicineOrganic chemistryMaterials scienceEnzymeAdvanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsNanoparticle-Based Drug Delivery