Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry
Satoshi Imazato, Tomoki Kohno, Ririko Tsuboi, Pasiree Thongthai, Hockin H.K. Xu, Haruaki Kitagawa
Abstract
Advancements in materials used for restorative and preventive treatment is being directed toward "bio-active" functionality. Incorporation of filler particles that release active components is a popular method to create bio-active materials, and many approaches are available to develop fillers with the ability to release components that provide "bio-protective" or "bio-promoting" properties; e.g. metal/calcium phosphate nanoparticles, multiple ion-releasing glass fillers, and non-biodegradable polymer particles. In this review paper, recent developments in cutting-edge filler technologies to release bio-active components are addressed and summarized according to their usefulness and functions, including control of bacterial infection, tooth strengthening, and promotion of tissue regeneration.