Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
Carly G.K. Ziegler, Vincent N. Miao, Anna H. Owings, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Taylor Christian, Adam Parker, Campbell B. Sindel, Molly W. Burger, Yilianys Pride, Mohammad Hasan, George Abraham, Michal Šenitko, Tanya O. Robinson, Alex K. Shalek, Sarah C. Glover, Bruce Horwitz, José Ordovás-Montañés
Abstract
"hillock"-like cells, and we identify genes associated with susceptibility, resistance, or infection response. Our study defines protective and detrimental responses to SARS-CoV-2, the direct viral targets of infection, and suggests that failed nasal epithelial anti-viral immunity may underlie and precede severe COVID-19.
Topics & Concepts
BiologyCoronavirus disease 2019 (COVID-19)ImmunitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakVirologyBetacoronavirusImmunologyCoronavirus InfectionsPandemicImmune systemInfectious disease (medical specialty)DiseaseOutbreakInternal medicineMedicineSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19