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Validation of an Allosteric Binding Site of Src Kinase Identified by Unbiased Ligand Binding Simulations

Victoria R. Mingione, Zachariah H. Foda, YiTing Paung, Hannah Philipose, Aziz M. Rangwala, Yibing Shan, Markus A. Seeliger

2022Journal of Molecular Biology15 citationsDOIOpen Access PDF

Topics & Concepts

Allosteric regulationBinding siteAllosteric enzymeDrug discoveryLigand (biochemistry)Computational biologySmall moleculeVirtual screeningBiologyPlasma protein bindingChemistryBiophysicsBiochemistryEnzymeReceptorMonoclonal and Polyclonal Antibodies ResearchProtein Degradation and InhibitorsProtein Structure and Dynamics
Validation of an Allosteric Binding Site of Src Kinase Identified by Unbiased Ligand Binding Simulations | Litcius