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The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression

Jinqiang Zhang, Saini Yi, Yahui Li, Chenghong Xiao, Chan Liu, Weike Jiang, Changgui Yang, Tao Zhou

2020Psychopharmacology39 citationsDOI

Topics & Concepts

TLR4Behavioural despair testPharmacologyMicrogliaKynurenine pathwayNeuroprotectionChemistryLipopolysaccharideHippocampusPrefrontal cortexInflammationAntidepressantEndocrinologyMedicineInternal medicineKynurenineBiochemistryAmino acidTryptophanPsychiatryCognitionTryptophan and brain disordersStress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms
The antidepressant effects of asperosaponin VI are mediated by the suppression of microglial activation and reduction of TLR4/NF-κB-induced IDO expression | Litcius