Genetic and pharmacological activation of Hedgehog signaling inhibits osteoclastogenesis and attenuates titanium particle-induced osteolysis partly through suppressing the JNK/c-Fos-NFATc1 cascade
Liwei Zhang, Yanjun Yang, Zirui Liao, Qingbai Liu, Xinhuan Lei, Meng Li, Saijilafu, Zunyi Zhang, Dun Hong, Min Zhu, Bin Li, Huilin Yang, Jianquan Chen
Abstract
. Mechanistically, Hh signaling hinders osteoclastogenesis partly through suppressing the JNK/c-Fos-NFATc1 cascade. Thus, Hh signaling may serve as a promising therapeutic target for the prevention and treatment of PPO and other osteolytic diseases.
Topics & Concepts
OsteolysisOsteoclastRANKLBone resorptionChemistrySignal transductionCancer researchHedgehog signaling pathwayOsteoblastCell biologySmoothenedMedicineActivator (genetics)Internal medicineIn vitroBiologyReceptorBiochemistrySurgeryBone health and treatmentsOrthopaedic implants and arthroplastyHedgehog Signaling Pathway Studies