Photo- and Cu-Mediated <sup>11</sup>C Cyanation of (Hetero)Aryl Thianthrenium Salts
Kevin Cheng, Eric Webb, Gregory D. Bowden, Jay S. Wright, Xia Shao, Melanie S. Sanford, Peter J. H. Scott
Abstract
C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.
Topics & Concepts
CyanationChemistryArylSurface modificationCombinatorial chemistryCatalysisOrganic chemistryAlkylPhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry