Coexpression of HOXA6 and PBX2 promotes metastasis in gastric cancer
Jianjiao Lin, Huiqiong Zhu, Linjie Hong, Weimei Tang, Jing Wang, Hong‐Song Hu, Xiaosheng Wu, Yaying Chen, Guangnan Liu, Qiong Yang, Jiaying Li, Yusi Wang, Zhizhao Lin, Yizhi Xiao, Weiyu Dai, Miaojvan Huang, Guoxin Li, Aimin Li, Jide Wang, Xiang Li, Side Liu
Abstract
, HOXA6 was shown to cooperate with PBX2 to enhance cell metastasis via orthotopic implantation. These data indicate that HOXA6 promotes cell proliferation, migration, and invasion and that the HOXA6-PBX2 axis may be a useful biomarker for disease progression in GC.
Topics & Concepts
Cancer researchBiologyMetastasisOncogeneCell migrationCancerCell growthDownregulation and upregulationCellCell cycleGeneGeneticsBiochemistryCancer-related gene regulationWnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene Regulation