Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses
Qiuyun Gu, Qing Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Pei‐Ying Wu
Abstract
. Metabolomic analysis revealed significant alterations in tryptophan metabolism, while transcriptome analysis identified genes involved in metabolic pathways. Correlation analyses underscored the importance of the gut-brain axis in mediating EGCG's effects. Overall, EGCG prevents obesity-induced precocious puberty by modulating the gut microbiota, altering metabolic pathways, and regulating hypothalamic gene expression.
Topics & Concepts
Precocious pubertyObesityEpigallocatechin gallateOmicsMedicineBioinformaticsGallateInternal medicineEndocrinologyBiologyPharmacologyAntioxidantBiochemistryPolyphenolHormoneTea Polyphenols and EffectsAdipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses