Knock-in rats with homozygous PSEN1 Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43
Marc D. Tambini, Luciano D'adamio
Abstract
Knock-in rats with homozygous PSEN1 L435F Alzheimer mutation are viable and show selective -secretase activity loss causing low A40/42 and high A43
Topics & Concepts
PSEN1MutationPresenilinAmyloid precursor protein secretaseBiologyMedicineGeneticsChemistryMolecular biologyAlzheimer's diseaseAmyloid precursor proteinInternal medicineDiseaseGeneComputational Drug Discovery MethodsAlzheimer's disease research and treatmentsProtein Structure and Dynamics