Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells
Dahong Yao, Jin Jiang, Hualin Zhang, Yelan Huang, Jian Huang, Jinhui Wang
Topics & Concepts
PI3K/AKT/mTOR pathwayHDAC6AutophagyChemistryCancer researchDiscovery and development of mTOR inhibitorsAcetylationRPTORHistone deacetylaseApoptosisHistoneBiochemistryBiologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPI3K/AKT/mTOR signaling in cancer