Night vision restored in days after decades of congenital blindness
Samuel G. Jacobson, Artur V. Cideciyan, Allen C. Ho, Alejandro J. Román, Vivian Wu, Alexandra V. Garafalo, Alexander Sumaroka, Arun K. Krishnan, Małgorzata Świder, Abraham A. Mascio, Christine N. Kay, Dan Yoon, Kenji P. Fujita, Sanford L. Boye, Igor V. Peshenko, Alexander M. Dizhoor, Sanford L. Boye
Abstract
units (1000-fold), nearing healthy rod vision. Quick activation of the complex molecular pathways from retinal photoreceptor to visual cortex and behavior is thus possible in patients even after being disabled and dormant for decades.
Topics & Concepts
Visual phototransductionGUCY2DRhodopsinBlindnessNeuroscienceRetinitis pigmentosaRetinalBiologyOpsinRetinaOphthalmologyMedicineOptometryStimulationGuanylate cyclase 2CCyclaseRetinal Development and DisordersRetinal Diseases and TreatmentsPhotoreceptor and optogenetics research