Combined sonodynamic therapy and X-ray radiation with methylene blue and gold nanoparticles coated with apigenin: Impact on MCF7 cell viability
Ali Neshasteh‐Riz, Zeinab Hormozi‐Moghaddam, Seyed Mohammad Amini, S. M. Taheri, Z. Abedi Kichi
Abstract
Background: This study investigates the efficacy of sonodynamic and low-dose radiation with methylene blue and gold nanoparticles coated with apigenin sonosensitizer on breast cancer cells.Method and Materials: HR-TEM, UV-visible, zeta -potential, FTIR, and DLS were used to confirm the synthesized gold nanoparticles coated with apigenin.The concentration of gold nanoparticles coated with apigenin and methylene blue was calculated, and then ultrasound and 2 Gy x-rays were used to irradiate them.Results: The results showed that sonodynamic therapy in combination with radiation at a concentration of 8 g/ml nanoparticles and 0.4 mol methylene blue had a significant effect on cell death (0.26 0.02).Conclusion: This study highlights the potential of sonodynamic therapy as a non-ionizing and non-invasive treatment, as well as the possibility of eliminating the side effects of cancer treatment by using green nanoparticles rather than chemical sensitizers.