Metal-free synthesis of <i>gem</i>-difluorinated heterocycles from enaminones and difluorocarbene precursors
Fei Wang, Rui Fu, Jie Chen, Jiaxin Rong, Enfu Wang, Jian Zhang, Zhengyu Zhang, Yaojia Jiang
Abstract
A cascade strategy to synthesise gem -difluorinated 2 H -furans from reactions of BrCF 2 CO 2 Et with enaminones has been described. The reactions work efficiently for a broad substrate scope and tolerate a variety of functional groups under very mild metal-free conditions.
Topics & Concepts
DifluorocarbeneCyclopropanationRegioselectivityChemistryBond cleavageTriple bondCombinatorial chemistryFunctional groupOrganic chemistryDouble bondCatalysisPolymerFluorine in Organic ChemistryCyclopropane Reaction MechanismsInorganic Fluorides and Related Compounds