Alamandine improves cardiac remodeling induced by transverse aortic constriction in mice
Mário Morais Silva, Fernando Souza-Neto, Itamar Couto Guedes de Jesus, Gleisy Kelly Neves Gonçalves, Melissa de Carvalho Santuchi, Bruno Sanches, Thaís Cristina de Alcântara-Leonídio, Marcos Barrouin Melo, Maria Aparecida Ribeiro Vieira, Sílvia Guatimosim, Robson A.S. Santos, Rafaela da Silva
Abstract
Alamandine is the newest identified component of the renin-angiotensin system protective arm. Considering the beneficial effects already described so far, alamandine is a promising target for cardiovascular disease treatment. We demonstrated for the first time that alamandine improves many aspects of cardiac remodeling induced by pressure overload, including cell hypertrophy, fibrosis, and oxidative stress markers.
Topics & Concepts
Internal medicineMedicineEndocrinologyFibrosisPhosphorylationRenin–angiotensin systemVentricular remodelingCardiac fibrosisMuscle hypertrophyHeart failureChemistryBiochemistryBlood pressureCardiac Fibrosis and RemodelingRenin-Angiotensin System StudiesHeart Failure Treatment and Management