The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction
Zhimin Qiu, Qicen Liu, Ling Jia Wang, Yingfen Xiong, Juan Wu, Meijian Wang, Xiluan Yan, Huangying Deng
Topics & Concepts
CisplatinGene knockdownApoptosisAcute kidney injuryTranscription factorCancer researchChemistryOxidative stressCell biologyTUNEL assayCaspase 7Programmed cell deathPharmacologyBiologyCaspase 3Internal medicineMedicineChemotherapyBiochemistryGeneChemotherapy-induced organ toxicity mitigationPharmacological Effects and Toxicity StudiesDrug Transport and Resistance Mechanisms