Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome
Yanan Hao, Yanni Feng, Xiaowei Yan, Liang Chen, Xiangping Ma, Xiangfang Tang, Ruqing Zhong, Zhongyi Sun, Manjree Agarwal, Hongfu Zhang, Yong Zhao
Abstract
HFD decreases male fertility via upsetting gut microbiota and transplantation of AOS-benefited gut microbiota (A10-FMT) improves gut microbiota to ameliorate HFD-reduced male fertility. Moreover, A10-FMT improved liver function to benefit the blood metabolome and simultaneously ameliorated the testicular microenvironment to turn the spermatogenesis process on. We demonstrated that AOS-benefited gut microbiota could be applied to treat infertile males with obesity and metabolic issues induced by HFD.
Topics & Concepts
MetabolomeGut floraBiologySemen qualitySemenSpermMale infertilityAndrologyInternal medicineDocosahexaenoic acidInfertilitySemen analysisPhysiologyEndocrinologyPolyunsaturated fatty acidFatty acidMedicinePregnancyImmunologyMetaboliteGeneticsBiochemistrySperm and Testicular FunctionReproductive System and PregnancySexual function and dysfunction studies