Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2
Anindya Dey, Shubhangi Prabhudesai, Yushan Zhang, Geeta Rao, Karthikeyan Thirugnanam, Md. Nazir Hossen, Shailendra Kumar Dhar Dwivedi, Ramani Ramchandran, Priyabrata Mukherjee, Resham Bhattacharya
Abstract
S/PHD2 axis may provide therapeutic opportunities for pathologies associated with HIF-1α dysregulation in chronic diseases.
Topics & Concepts
ATP synthaseCell biologyChemistryComputer scienceBiologyBiochemistryEnzymeCancer, Hypoxia, and MetabolismSulfur Compounds in BiologyAmino Acid Enzymes and Metabolism