Evidence for Network Evolution in an Arabidopsis Interactome Map
Y.-Y. Ahn, A.-L. Barabasi, Padmavathi Balumuri, P. Gilles, B. J. Gutierrez, M. Galli, A. Dricot, A. MacWilliams, M. E. Cusick, Rosa Cheuk Kim, F. Gebreab, Chang N. Kim, D. Byrdsong, L. Gai, H. Chen, J Dangl, A.-R. Carvunis, M. Dreze, D. E. Hill, S. J. Pevzner, J. D. Chesnut, J. R. Ecker, G. Ghoshal, M. Tasan, P. Braun, V. Bautista, C. Lurin, M. Duarte, C. Fan, B. Charloteaux, T. Hao, Carolina de los Reyes
Abstract
Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing ~6,200 highly reliable interactions between ~2,700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.