GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation
Yimin Cheng, Guobin Zheng, Heming Huang, Jian Ni, Yun Zhao, Yuting Sun, Yingxin Chang, Shangjing Liu, Feng He, Dan Li, Yuying Guo, Yaodong Miao, Mengxin Xu, Dongyue Wang, Yunsha Zhang, Yunqing Hua, Shujuan Yang, Guanwei Fan, Chuanrui Ma
Abstract
GLSP alleviates vascular aging by exerting antioxidant effects through the activation of the Sirt7-Nrf2 axis, providing a promising new strategy for delaying vascular aging, atherosclerosis and vascular calcification.
Topics & Concepts
KEAP1AcetylationDissociation (chemistry)ChemistryCell biologyBiologyBiochemistryTranscription factorGenePhysical chemistryHistone Deacetylase Inhibitors ResearchSirtuins and Resveratrol in MedicineGDF15 and Related Biomarkers