Pyrimidine-Piperazine Hybrids; Recent Synthesis and Biological Activities
Mohammed Al‐Ghorbani, Moustafa A. Gouda, Mohammed Baashen, Lakshmi Ranganatha V.
Abstract
Pyrimidine and piperazine are well known as being the backbone of many bulky compounds and a vital core structure in approved drugs; previous studies have shown that combining a pyridine ring with a piperazine moiety within a single structural framework enhances biological activity. Despite vast resources enriched with a heterocyclic hybrid structure, a few reported studied on the synthesis and biological activities of pyrimidine-piperazine analogs were discussed. In this review, we summarize current design methods for the construction of pyrimidine-piperazine hybrids by coupling substituted piperazine on various positions of a pyrimidine ring and studied their biological studies.