Massively parallel assessment of human variants with base editor screens
Ruth E. Hanna, Mudra Hegde, Christian Fagre, Peter C. DeWeirdt, Annabel K. Sangree, Zsofia M Szegletes, Audrey L Griffith, Marissa N. Feeley, Kendall R Sanson, Yossef Baidi, Luke W. Koblan, David R. Liu, James T. Neal, John G. Doench
Topics & Concepts
BiologyCRISPRGenetic screenComputational biologyGeneticsLoss functionPoint mutationGeneFunction (biology)Cas9MutationPhenotypeCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsEvolution and Genetic Dynamics