The Warburg effect drives dedifferentiation through epigenetic reprogramming
Haowen Jiang, Mohamed Jedoui, Jiangbin Ye
Abstract
German biochemist and cell physiologist, Otto H. Warburg ( [Figure 1][1] ), made a groundbreaking discovery in 1923. Specifically, tumors were shown to consume large amounts of glucose and ferment glucose into lactate, even in the presence of oxygen—a phenomenon termed “aerobic glycolysis”[1][
Topics & Concepts
Warburg effectAnaerobic glycolysisGlycolysisReprogrammingEpigeneticsBiochemistBiologyCell biologyChemistryCellBiochemistryMetabolismArtClassicsGeneCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyEpigenetics and DNA Methylation