Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
Jean‐Christophe Beltra, Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi, Leon Su, Lora K. Picton, Shin Foong Ngiow, Yuki Muroyama, Valentina Casella, Yinghui Huang, Josephine R. Giles, Divij Mathew, Jonathan Belman, Max Klapholz, Hélène Decaluwe, Alexander C. Huang, Shelley L. Berger, K. Christopher García, E. John Wherry
Topics & Concepts
STAT5BiologyEffectorEpigeneticsCell biologyCD8Cytotoxic T cellTranscription factorstatImmunologyCancer researchAntigenSignal transductionSTAT3GeneticsGeneIn vitroImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology