g‐C<sub>3</sub>N<sub>4</sub>/Co Nanohybrids for Ultra‐sensitive Simultaneous Detection of Uric Acid and Dopamine
Minmin Wang, Mengke Zhang, Jinli Zhu, Jin Wang, Lanping Hu, Tongming Sun, Miao Wang, Yanfeng Tang
Abstract
Abstract A highly sensitive and selective electrochemical sensor based on g‐C 3 N 4 /Co nanohybrids was developed for simultaneous detection of uric acid and dopamine. The g‐C 3 N 4 /Co nanohybrid modified electrode shows excellent catalytic response towards the oxidation of uric acid and dopamine, with an anodic peak during differential pulse voltammetry at around 300 mV and 150 mV (Ag/AgCl) taken at pH 7.4, respectively. Good linear relationships between peak current intensities and concentrations were obtained in the range of 1 to 1000 μM and 1 to 400 μM for uric acid and dopamine, and the limit of detection (S/N=3) was 0.4 μM and 0.5 μM, respectively. Further analysis revealed the key role of synergistic effect of Co NPs and g‐C 3 N 4 in boosting the oxidation of uric acid and dopamine. The newly developed sensor was successfully applied to human serum samples for a fast‐electrochemical determination of uric acid. These results demonstrate that the g‐C 3 N 4 /Co nanohybrid is a promising candidate of advanced electrode material in electrochemical sensing and other electrocatalytic applications.