Analysis of the Genomics and Mouse Virulence of an Emergent Clone of Streptococcus dysgalactiae Subspecies <i>equisimilis</i>
Stephen B. Beres, Randall J. Olsen, S. Wesley Long, Jesus M. Eraso, Sarrah Boukthir, Ahmad Faili, Samer Kayal, James M. Musser
Abstract
Our studies addressed a critical knowledge gap in understanding the genomics and virulence of the bacterial pathogen Streptococcus dysgalactiae subsp. equisimilis . S. dysgalactiae subsp. equisimilis strains are responsible for a recent increase in severe human infections in some countries. We determined that certain S. dysgalactiae subsp. equisimilis strains are genetically descended from a common ancestor and that these strains can cause severe infections in a mouse model of necrotizing myositis.
Topics & Concepts
Streptococcus dysgalactiaeBiologyVirulenceMicrobiologyStreptococcus pyogenesPathogenesisMobile genetic elementsPathogenGenomeGenomicsGeneticsVirologyGeneStreptococcusBacteriaImmunologyStreptococcus agalactiaeStaphylococcus aureusStreptococcal Infections and TreatmentsBacterial Identification and Susceptibility TestingAntimicrobial Resistance in Staphylococcus