Novel Humanized Peripheral Blood Mononuclear Cell Mouse Model with Delayed Onset of Graft-versus-Host Disease for Preclinical HIV Research
Leo Holguin, Liliana Echavarria, John C. Burnett
Abstract
Currently, there is no cure or vaccine for HIV infection; thus, continued research is needed to end the HIV pandemic. While many animal models are used in HIV research, none is used more than the humanized mouse model. A major limitation with current humanized mouse models is the development of graft-versus-host disease (GVHD). Here, we describe a novel humanized-PBMC mouse model that has a delayed onset GVHD development and supports and models HIV infection comparably to well-established humanized mouse models.
Topics & Concepts
Humanized mouseViremiaPeripheral blood mononuclear cellImmunologyBiologyImmune systemDiseaseT cellVirologyGraft-versus-host diseaseTumor necrosis factor alphaKnockout mouseCancer researchLentivirusTransplantationMedicineHematopoietic stem cell transplantationCytokineCytotoxic T cellVaccine efficacyViral loadCellHematologyHIV Research and TreatmentHIV-related health complications and treatmentsBiological Research and Disease Studies