Exercise reduces metabolic burden while altering the immune system in aged mice
Kyeong Jin Yoon, Aram Ahn, Soo Hong Park, Seung Hee Kwak, Seong Eun Kwak, Won‐Sang Lee, Yong Ryoul Yang, Minji Kim, Hyun Mu Shin, Hang‐Rae Kim, Hyo Youl Moon
Abstract
T cells, eosinophils, and neutrophils, in the stromal vascular fraction of WAT. In addition, it has been shown through transcriptome analysis of WAT that exercise can activate pathways involved in the interaction between WAT and immune cells, in particular NK cells, in aged mice. These results suggest that exercise has a profound effect on changes in immune-cell distribution and senescent-cell scavenging in WAT of aged mice, eventually affecting overall energy metabolism toward a more youthful state.
Topics & Concepts
Immune systemMedicineImmunologyBiologyExercise and Physiological ResponsesAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases