<i>C</i>-Methylation controls the biosynthetic programming of alternapyrone
Jaiyfungkhong Phakeovilay, Witcha Imaram, Supachai Vuttipongchaikij, Waraporn Bunnak, Colin M. Lazarus, Pakorn Wattana‐Amorn
Abstract
Mutations of the C -methyltransferase ( C -MeT) domain of alternapyrone polyketide synthase (AltPKS) resulted in no production of any non-methylated polyketides indicating the importance of C -methylation for biosynthetic programming of alternapyrone.
Topics & Concepts
ChemistryPolyeneMethylationMethyltransferasePolyketideBiosynthesisPyronePolyketide synthaseBiochemistryEnzymeStereochemistryDNAPlant Gene Expression AnalysisMicrobial Natural Products and BiosynthesisPlant and fungal interactions