The deregulation of arachidonic acid metabolism in ovarian cancer
Qiuyi Xia, Wen Gao, Jintao Yang, Zhifang Xing, Zhaodong Ji
Abstract
Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent studies have indicated that AA and its metabolites play significant regulatory roles in the onset and progression of ovarian cancer. This article examines the recent research advancements on the correlation between AA metabolites and ovarian cancer, both domestically and internationally, suggesting their potential use as biological markers for early diagnosis, targeted therapy, and prognosis monitoring.
Topics & Concepts
Arachidonic acidOvarian cancerPolyunsaturated fatty acidCancerMetabolismCytochrome P450Cancer researchFatty acid metabolismCytochrome c oxidaseBiochemistryPharmacologyMedicineChemistryFatty acidEnzymeInternal medicineBiologyBioinformaticsCancer, Lipids, and MetabolismMetabolomics and Mass Spectrometry StudiesPeroxisome Proliferator-Activated Receptors