<i>In Vitro</i> Susceptibility of <i>Plasmodium falciparum</i> Isolates from the China-Myanmar Border Area to Piperaquine and Association with Candidate Markers
Yu Si, Weilin Zeng, Na Li, Chengqi Wang, Faiza Amber Siddiqui, Jie Zhang, Liang Pi, Xi He, Luyi Zhao, Siqi Wang, Hui Zhao, Xinxin Li, Qi Yang, Jun Miao, Zhaoqing Yang, Liwang Cui
Abstract
Plasmodium falciparum from the Greater Mekong subregion has evolved resistance to the artemisinin-based combination therapy dihydroartemisinin and the partner drug piperaquine. To monitor the potential westward spread or independent evolution of piperaquine resistance, we evaluated the in vitro susceptibility of 120 P. falciparum isolates collected at the China-Myanmar border during 2007 to 2016.
Topics & Concepts
PiperaquinePlasmodium falciparumArtemisininDihydroartemisininMalariaBiologyChinaDrug resistanceVirologyGeographyMicrobiologyImmunologyArchaeologyMalaria Research and ControlComputational Drug Discovery MethodsHIV/AIDS drug development and treatment