Uptake mechanisms of cell-internalizing nucleic acid aptamers for applications as pharmacological agents
Samira Husen Alamudi, Michiko Kimoto, Ichiro Hirao
Abstract
a cell-based selection process, along with their challenges and optimization strategies. We highlight the cellular uptake routes adopted by the aptamers and also their intracellular fate after the uptake, to give an overview of their mechanism of action for applications as promising pharmacological agents.
Topics & Concepts
AptamerNucleic acidCellChemistryComputational biologyBiologyBiochemistryMolecular biologyAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry