Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance
Wanshu Ma, Hyea Jin Gil, Xiaolei Liu, Lauren Diebold, Marc A. Morgan, Michael J. Oxendine-Burns, Peng Gao, Navdeep S. Chandel, Guillermo Oliver
Abstract
). Our findings indicate that by sensing the LEC differentiation status and microenvironmental metabolic conditions, mitochondrial complex III regulates the critical Prox1-Vegfr3 feedback loop and, therefore, LEC fate specification and maintenance.
Topics & Concepts
MitochondrionRespirationLoop (graph theory)Feedback loopLymphatic systemCell biologyCell fate determinationBiologyChemistryComputer scienceBiochemistryAnatomyImmunologyComputer securityMathematicsTranscription factorGeneCombinatoricsLymphatic System and DiseasesVascular Malformations and HemangiomasLymphatic Disorders and Treatments